| 1. Jornada | 16.07.2021 | River Plate II | - | Colón de Santa Fe II | 1:2 | ||||
| 5. Jornada | 06.08.2021 | Godoy Cruz II | - | River Plate II | 0:1 | ||||
| 6. Jornada | 13.08.2021 | River Plate II | - | Vélez Sarsfield II | 1:2 | ||||
| 7. Jornada | 19.08.2021 | Gimnasia de La Plata II | - | River Plate II | 3:1 | ||||
| 8. Jornada | 23.08.2021 | River Plate II | - | Aldosivi II | 3:0 | ||||
| 9. Jornada | 31.08.2021 | Sarmiento de Junín II | - | River Plate II | 3:1 | ||||
| 13. Jornada | 24.09.2021 | Central Córdoba SdE II | - | River Plate II | 1:2 | ||||
| 14. Jornada | 01.10.2021 | River Plate II | - | Boca Juniors II | 0:3 | ||||
| 16. Jornada | 15.10.2021 | River Plate II | - | San Lorenzo II | 1:3 | ||||
| 17. Jornada | 20.10.2021 | Talleres de Córdoba II | - | River Plate II | 1:0 | ||||
| 18. Jornada | 26.10.2021 | River Plate II | - | Argentinos Juniors II | 0:3 | ||||
| 19. Jornada | 31.10.2021 | Estudiantes II | - | River Plate II | 0:0 | ||||
| 21. Jornada | 19.11.2021 | Platense II | - | River Plate II | 5:2 | ||||
| 22. Jornada | 23.11.2021 | River Plate II | - | Racing Club II | 1:2 | ||||
| 23. Jornada | 28.11.2021 | Rosario Central II | - | River Plate II | 2:0 |
Argentina