| 21. Jornada | 15.01.2022 | Guingamp | - | Grenoble Foot 38 | 0:0 |  |
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| 23. Jornada | 05.02.2022 | Guingamp | - | AJ Auxerre | 1:1 | ||||
| 24. Jornada | 12.02.2022 | AC Ajaccio | - | Guingamp | 0:1 | ||||
| 25. Jornada | 19.02.2022 | Guingamp | - | Paris FC | 1:1 | ||||
| 26. Jornada | 26.02.2022 | Guingamp | - | Chamois Niortais | 1:0 | ||||
| 27. Jornada | 05.03.2022 | FC Sochaux | - | Guingamp | 1:0 | ||||
| 28. Jornada | 12.03.2022 | Guingamp | - | US Quevilly-Rouen | 1:1 | |
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| 29. Jornada | 15.03.2022 | Rodez AF | - | Guingamp | 1:1 | ||||
| 30. Jornada | 19.03.2022 | Guingamp | - | AS Nancy Lorraine | 3:1 | ||||
| 31. Jornada | 02.04.2022 | Nîmes Olympique | - | Guingamp | 0:2 | ||||
| 32. Jornada | 09.04.2022 | Guingamp | - | Toulouse | 2:4 | |
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| 33. Jornada | 16.04.2022 | Bastia | - | Guingamp | 1:2 | ||||
| 34. Jornada | 19.04.2022 | Guingamp | - | Pau FC | 3:0 | |
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| 35. Jornada | 22.04.2022 | Dijon FCO | - | Guingamp | 3:3 | ||||
| 36. Jornada | 30.04.2022 | Guingamp | - | Caen | 2:1 | ||||
| 37. Jornada | 07.05.2022 | USL Dunkerque | - | Guingamp | 1:3 | |
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| 38. Jornada | 14.05.2022 | Guingamp | - | Havre AC | 2:1 |
Francia