| 1. Jornada | 08.08.2021 | Montpellier | - | Marsella | 2:3 | ||||
| 2. Jornada | 15.08.2021 | Stade de Reims | - | Montpellier | 3:3 |  |
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| 3. Jornada | 22.08.2021 | Montpellier | - | Lorient | 3:1 | ||||
| 4. Jornada | 29.08.2021 | Lille | - | Montpellier | 2:1 | ||||
| 5. Jornada | 12.09.2021 | Montpellier | - | Saint-Étienne | 2:0 | ||||
| 6. Jornada | 19.09.2021 | Troyes | - | Montpellier | 1:1 |  |
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| 8. Jornada | 25.09.2021 | París Saint-Germain | - | Montpellier | 2:0 | ||||
| 14. Jornada | 20.11.2021 | Rennes | - | Montpellier | 2:0 | ||||
| 18. Jornada | 11.12.2021 | Stade Brestois 29 | - | Montpellier | 0:4 | ||||
| 19. Jornada | 22.12.2021 | Montpellier | - | Angers | 4:1 | ||||
| 25. Jornada | 20.02.2022 | Lorient | - | Montpellier | 0:1 | ||||
| 26. Jornada | 25.02.2022 | Montpellier | - | Rennes | 2:4 | ||||
| 27. Jornada | 06.03.2022 | Nantes | - | Montpellier | 2:0 | ||||
| 29. Jornada | 20.03.2022 | Girondins de Burdeos | - | Montpellier | 0:2 | ||||
| 36. Jornada | 08.05.2022 | Clermont Foot 63 | - | Montpellier | 2:1 | ||||
| 37. Jornada | 14.05.2022 | Montpellier | - | París Saint-Germain | 0:4 |
Brasil