| 9. Jornada | 16.09.2021 | Atlético San Luis [Sub 20] | - | Club Tijuana [Sub 20] | 3:0 | ||||
| 14. Jornada | 21.09.2021 | FC Juárez [Sub 20] | - | Atlético San Luis [Sub 20] | 1:2 | ||||
| 10. Jornada | 26.09.2021 | Deportivo Toluca [Sub 20] | - | Atlético San Luis [Sub 20] | 2:0 | ||||
| 11. Jornada | 29.09.2021 | Atlético San Luis [Sub 20] | - | UANL Tigres [Sub 20] | 2:1 | ||||
| 12. Jornada | 02.10.2021 | Club León [Sub 20] | - | Atlético San Luis [Sub 20] | 2:0 | ||||
| 16. Jornada | 31.10.2021 | Atlético San Luis [Sub 20] | - | CF Monterrey [Sub 20] | 3:1 | ||||
| 5. Jornada | 03.11.2021 | CF Pachuca [Sub 20] | - | Atlético San Luis [Sub 20] | 1:3 | ||||
| 17. Jornada | 07.11.2021 | Santos Laguna [Sub 20] | - | Atlético San Luis [Sub 20] | 2:1 |
México