| 1. Jornada | 08.08.2021 | Rennes | - | RC Lens | 1:1 | ||||
| 3. Jornada | 21.08.2021 | Mónaco | - | RC Lens | 0:2 | ||||
| 4. Jornada | 29.08.2021 | RC Lens | - | Lorient | 2:2 | ||||
| 5. Jornada | 12.09.2021 | Girondins de Burdeos | - | RC Lens | 2:3 | ||||
| 6. Jornada | 18.09.2021 | RC Lens | - | Lille | 1:0 | ||||
| 7. Jornada | 22.09.2021 | RC Lens | - | RC Strasbourg | 0:1 | ||||
| 9. Jornada | 01.10.2021 | RC Lens | - | Stade de Reims | 2:0 | ||||
| 11. Jornada | 24.10.2021 | RC Lens | - | FC Metz | 4:1 | ||||
| 13. Jornada | 05.11.2021 | RC Lens | - | Troyes | 4:0 | ||||
| 15. Jornada | 26.11.2021 | RC Lens | - | Angers | 2:2 | ||||
| 16. Jornada | 01.12.2021 | Clermont Foot 63 | - | RC Lens | 2:2 | ||||
| 17. Jornada | 04.12.2021 | RC Lens | - | París Saint-Germain | 1:1 | ||||
| 18. Jornada | 10.12.2021 | Nantes | - | RC Lens | 3:2 | ||||
| 19. Jornada | 22.12.2021 | Niza | - | RC Lens | 2:1 | ||||
| 23. Jornada | 06.02.2022 | Lorient | - | RC Lens | 2:0 |  |
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| 32. Jornada | 16.04.2022 | Lille | - | RC Lens | 1:2 |  |
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| 33. Jornada | 20.04.2022 | RC Lens | - | Montpellier | 2:0 | ||||
| 38. Jornada | 21.05.2022 | RC Lens | - | Mónaco | 2:2 |
Francia