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| 24.09.2022 | 00:00 | Huracán | - | Banfield | 3:1 (2:1) | |
| 00:00 | Godoy Cruz | - | Boca Juniors | 0:1 (0:1) | ||
| 18:00 | Sarmiento de Junín | - | Arsenal de Sarandí | 2:0 (1:0) | ||
| 18:00 | Defensa y Justicia | - | Patronato de Paraná | 2:1 (1:1) | ||
| 20:30 | CA Lanús | - | San Lorenzo | 2:0 (1:0) | ||
| 23:00 | River Plate | - | Talleres de Córdoba | 0:1 (0:0) | ||
| 25.09.2022 | 01:30 | Independiente | - | Newell's Old Boys | 1:0 (0:0) | |
| 20:30 | Gimnasia de La Plata | - | Tigre | 0:1 (0:1) | ||
| 20:30 | Rosario Central | - | Platense | 1:1 (1:1) | ||
| 23:00 | Racing Club | - | Unión de Santa Fe | 2:1 (0:0) | ||
| 26.09.2022 | 01:30 | Atlético Tucumán | - | Estudiantes | 3:1 (1:1) | |
| 01:30 | Vélez Sarsfield | - | Barracas Central | 1:0 (1:0) | ||
| 22:00 | Aldosivi | - | Central Córdoba SdE | 0:3 (0:0) | ||
| 22:00 | Colón de Santa Fe | - | Argentinos Juniors | 0:4 (0:2) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlético Tucumán | 21 | 11 | 8 | 2 | 26:12 | 14 | 41 |
| 2 |
|
Boca Juniors | 21 | 12 | 3 | 6 | 26:22 | 4 | 39 |
| 3 |
|
Racing Club | 21 | 10 | 7 | 4 | 28:16 | 12 | 37 |
| 4 |
|
Huracán | 21 | 9 | 10 | 2 | 26:15 | 11 | 37 |
| 5 |
|
Gimnasia de La Plata | 21 | 10 | 6 | 5 | 21:12 | 9 | 36 |
| 6 |
|
Argentinos Juniors | 21 | 10 | 3 | 8 | 26:20 | 6 | 33 |
| 7 |
|
River Plate | 21 | 9 | 5 | 7 | 29:18 | 11 | 32 |
| 8 |
|
Godoy Cruz | 21 | 9 | 5 | 7 | 23:22 | 1 | 32 |
| 9 |
|
Tigre | 21 | 7 | 9 | 5 | 29:24 | 5 | 30 |
| 10 |
|
Platense | 21 | 7 | 9 | 5 | 19:16 | 3 | 30 |
| 11 |
|
Newell's Old Boys | 21 | 8 | 5 | 8 | 19:19 | 0 | 29 |
| 12 |
|
Patronato de Paraná | 21 | 7 | 7 | 7 | 24:22 | 2 | 28 |
| 13 |
|
Sarmiento de Junín | 21 | 8 | 4 | 9 | 22:24 | -2 | 28 |
| 14 |
|
Defensa y Justicia | 21 | 7 | 7 | 7 | 20:22 | -2 | 28 |
| 15 |
|
San Lorenzo | 21 | 5 | 12 | 4 | 23:21 | 2 | 27 |
| 16 |
|
Independiente | 21 | 7 | 6 | 8 | 23:23 | 0 | 27 |
| 17 |
|
Central Córdoba SdE | 21 | 8 | 3 | 10 | 27:28 | -1 | 27 |
| 18 |
|
Estudiantes | 21 | 7 | 6 | 8 | 20:23 | -3 | 27 |
| 19 |
|
Unión de Santa Fe | 21 | 7 | 6 | 8 | 24:28 | -4 | 27 |
| 20 |
|
Barracas Central | 21 | 7 | 6 | 8 | 24:29 | -5 | 27 |
| 21 |
|
Talleres de Córdoba | 21 | 6 | 8 | 7 | 19:19 | 0 | 26 |
| 22 |
|
Banfield | 21 | 6 | 7 | 8 | 21:24 | -3 | 25 |
| 23 |
|
Rosario Central | 21 | 6 | 7 | 8 | 16:20 | -4 | 25 |
| 24 |
|
Arsenal de Sarandí | 21 | 4 | 11 | 6 | 21:24 | -3 | 23 |
| 25 |
|
Vélez Sarsfield | 21 | 3 | 10 | 8 | 23:28 | -5 | 19 |
| 26 |
|
Colón de Santa Fe | 21 | 4 | 7 | 10 | 15:28 | -13 | 19 |
| 27 |
|
CA Lanús | 21 | 4 | 5 | 12 | 19:30 | -11 | 17 |
| 28 |
|
Aldosivi | 21 | 3 | 4 | 14 | 12:36 | -24 | 13 |
