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| I | San Lorenzo | - | Santos FC | 1:3 (0:2) | ||
| V | Santos FC | - | San Lorenzo | 2:2 (1:0) | ||
| I: 07.04.2021 02:30 | V: 14.04.2021 02:30 | Campeones: Santos FC | ||||
| I | Libertad | - | Atlético Nacional | 1:0 (0:0) | ||
| V | Atlético Nacional | - | Libertad | 4:1 (1:1) | ||
| I: 08.04.2021 02:30 | V: 15.04.2021 02:30 | Campeones: Atlético Nacional | ||||
| I | Bolívar | - | Atlético Junior | 2:1 (1:1) | ||
| V | Atlético Junior | - | Bolívar | 3:0 (1:0) | ||
| I: 09.04.2021 02:30 | V: 16.04.2021 02:30 | Campeones: Atlético Junior | ||||
| I | Independiente del Valle | - | Grêmio Porto Alegre | 2:1 (0:1) | ||
| V | Grêmio Porto Alegre | - | Independiente del Valle | 1:2 (1:1) | ||
| I: 10.04.2021 00:15 | V: 15.04.2021 00:15 | Campeones: Independiente del Valle | ||||
