 |
 |
|
|
| 11.09.2021 | 19:00 | Cruz Azul | - | Deportivo Toluca | 2:1 (0:1) | |
| 12.09.2021 | 17:00 | FC Juárez | - | CF América | 1:1 (0:0) | |
| 17:30 | CF Monterrey | - | Club Tijuana | 4:0 (1:0) | ||
| 19:00 | Puebla FC | - | Gallos Blancos | 0:1 (0:1) | ||
| 13.09.2021 | 00:00 | Atlético San Luis | - | Atlas Guadalajara | 0:0 (0:0) | |
| 04:00 | UANL Tigres | - | CF Pachuca | 5:0 (3:0) | ||
| 04:00 | Santos Laguna | - | Deportivo Guadalajara | 5:4 (2:2) | ||
| 14.09.2021 | 00:00 | Club Necaxa | - | Mazatlán FC | 3:0 (2:0) | |
| 02:00 | Club León | - | Pumas UNAM | 0:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UANL Tigres | 9 | 9 | 0 | 0 | 35:3 | 32 | 27 |
| 2 |
|
CF Monterrey | 9 | 8 | 1 | 0 | 20:2 | 18 | 25 |
| 3 |
|
Deportivo Guadalajara | 9 | 7 | 1 | 1 | 24:8 | 16 | 22 |
| 4 |
|
Santos Laguna | 9 | 6 | 2 | 1 | 26:11 | 15 | 20 |
| 5 |
|
CF América | 9 | 6 | 2 | 1 | 20:8 | 12 | 20 |
| 6 |
|
Club Tijuana | 9 | 4 | 3 | 2 | 12:8 | 4 | 15 |
| 7 |
|
Cruz Azul | 9 | 4 | 2 | 3 | 8:13 | -5 | 14 |
| 8 |
|
Atlas Guadalajara | 9 | 3 | 3 | 3 | 11:12 | -1 | 12 |
| 9 |
|
Club Necaxa | 9 | 3 | 1 | 5 | 7:21 | -14 | 10 |
| 10 |
|
Gallos Blancos | 9 | 2 | 3 | 4 | 11:12 | -1 | 9 |
| 11 |
|
CF Pachuca | 9 | 2 | 3 | 4 | 12:16 | -4 | 9 |
| 12 |
|
Puebla FC | 9 | 3 | 0 | 6 | 12:17 | -5 | 9 |
| 13 |
|
Pumas UNAM | 9 | 1 | 5 | 3 | 7:10 | -3 | 8 |
| 14 |
|
Club León | 9 | 2 | 2 | 5 | 11:18 | -7 | 8 |
| 15 |
|
Deportivo Toluca | 9 | 2 | 1 | 6 | 8:16 | -8 | 7 |
| 16 |
|
FC Juárez | 9 | 1 | 2 | 6 | 5:17 | -12 | 5 |
| 17 |
|
Atlético San Luis | 9 | 1 | 2 | 6 | 5:22 | -17 | 5 |
| 18 |
|
Mazatlán FC | 9 | 0 | 1 | 8 | 4:24 | -20 | 1 |
| Playoff |
