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| 20.11.2021 | 11:30 | Hatayspor | - | Antalyaspor | 3:1 (1:1) | |
| 14:00 | Giresunspor | - | Yeni Malatyaspor | 1:0 (0:0) | ||
| 14:00 | İstanbul Başakşehir | - | Sivasspor | 2:1 (2:0) | ||
| 17:00 | Alanyaspor | - | Beşiktaş | 2:0 (1:0) | ||
| 21.11.2021 | 11:30 | Kasımpaşa SK | - | Fatih Karagümrük SK | 1:3 (1:3) | |
| 14:00 | Altay Izmir | - | Adana Demirspor | 1:3 (0:1) | ||
| 14:00 | Konyaspor | - | Çaykur Rizespor | 3:0 (1:0) | ||
| 17:00 | Galatasaray | - | Fenerbahçe | 1:2 (1:1) | ||
| 22.11.2021 | 18:00 | Kayserispor | - | Göztepe | 1:1 (1:0) | |
| 18:00 | Trabzonspor | - | Gaziantep FK | 3:0 (3:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Trabzonspor | 13 | 10 | 3 | 0 | 27:11 | 16 | 33 |
| 2 |
|
Hatayspor | 13 | 8 | 2 | 3 | 23:10 | 13 | 26 |
| 3 |
|
Konyaspor | 13 | 7 | 5 | 1 | 21:10 | 11 | 26 |
| 4 |
|
Alanyaspor | 13 | 7 | 3 | 3 | 20:19 | 1 | 24 |
| 5 |
|
Fenerbahçe | 13 | 7 | 2 | 4 | 19:16 | 3 | 23 |
| 6 |
|
Fatih Karagümrük SK | 13 | 6 | 4 | 3 | 21:16 | 5 | 22 |
| 7 |
|
İstanbul Başakşehir | 13 | 7 | 0 | 6 | 20:16 | 4 | 21 |
| 8 |
|
Galatasaray | 13 | 6 | 3 | 4 | 19:17 | 2 | 21 |
| 9 |
|
Beşiktaş | 13 | 6 | 2 | 5 | 21:17 | 4 | 20 |
| 10 |
|
Adana Demirspor | 13 | 5 | 4 | 4 | 20:18 | 2 | 19 |
| 11 |
|
Altay Izmir | 13 | 5 | 1 | 7 | 18:21 | -3 | 16 |
|
Kayserispor | 13 | 4 | 4 | 5 | 18:21 | -3 | 16 | |
| 13 |
|
Antalyaspor | 13 | 4 | 3 | 6 | 15:20 | -5 | 15 |
| 14 |
|
Gaziantep FK | 13 | 4 | 3 | 6 | 14:19 | -5 | 15 |
| 15 |
|
Sivasspor | 13 | 2 | 7 | 4 | 16:15 | 1 | 13 |
| 16 |
|
Giresunspor | 13 | 3 | 4 | 6 | 8:12 | -4 | 13 |
| 17 |
|
Yeni Malatyaspor | 13 | 4 | 0 | 9 | 12:23 | -11 | 12 |
| 18 |
|
Göztepe | 13 | 2 | 4 | 7 | 12:19 | -7 | 10 |
| 19 |
|
Kasımpaşa SK | 13 | 2 | 3 | 8 | 13:21 | -8 | 9 |
| 20 |
|
Çaykur Rizespor | 13 | 2 | 1 | 10 | 11:27 | -16 | 7 |
| Champions League | |
| CL Ronda previa | |
| ECL Ronda previa | |
| Descenso |
