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| 26.11.2021 | 18:00 | Adana Demirspor | - | Kasımpaşa SK | 0:0 (0:0) | |
| 18:00 | İstanbul Başakşehir | - | Altay Izmir | 0:0 (0:0) | ||
| 27.11.2021 | 11:30 | Antalyaspor | - | Alanyaspor | 3:0 (1:0) | |
| 14:00 | Çaykur Rizespor | - | Kayserispor | 1:0 (0:0) | ||
| 17:00 | Beşiktaş | - | Giresunspor | 0:4 (0:1) | ||
| 28.11.2021 | 11:30 | Gaziantep FK | - | Konyaspor | 3:2 (1:1) | |
| 14:00 | Fatih Karagümrük SK | - | Trabzonspor | 0:2 (0:1) | ||
| 14:00 | Sivasspor | - | Hatayspor | 4:0 (2:0) | ||
| 17:00 | Yeni Malatyaspor | - | Galatasaray | 0:0 (0:0) | ||
| 29.11.2021 | 18:00 | Göztepe | - | Fenerbahçe | 1:1 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Trabzonspor | 14 | 11 | 3 | 0 | 29:11 | 18 | 36 |
| 2 |
|
Konyaspor | 14 | 7 | 5 | 2 | 23:13 | 10 | 26 |
| 3 |
|
Hatayspor | 14 | 8 | 2 | 4 | 23:14 | 9 | 26 |
| 4 |
|
Fenerbahçe | 14 | 7 | 3 | 4 | 20:17 | 3 | 24 |
| 5 |
|
Alanyaspor | 14 | 7 | 3 | 4 | 20:22 | -2 | 24 |
| 6 |
|
İstanbul Başakşehir | 14 | 7 | 1 | 6 | 20:16 | 4 | 22 |
| 7 |
|
Fatih Karagümrük SK | 14 | 6 | 4 | 4 | 21:18 | 3 | 22 |
| 8 |
|
Galatasaray | 14 | 6 | 4 | 4 | 19:17 | 2 | 22 |
| 9 |
|
Adana Demirspor | 14 | 5 | 5 | 4 | 20:18 | 2 | 20 |
| 10 |
|
Beşiktaş | 14 | 6 | 2 | 6 | 21:21 | 0 | 20 |
| 11 |
|
Antalyaspor | 14 | 5 | 3 | 6 | 18:20 | -2 | 18 |
| 12 |
|
Gaziantep FK | 14 | 5 | 3 | 6 | 17:21 | -4 | 18 |
| 13 |
|
Altay Izmir | 14 | 5 | 2 | 7 | 18:21 | -3 | 17 |
| 14 |
|
Sivasspor | 14 | 3 | 7 | 4 | 20:15 | 5 | 16 |
| 15 |
|
Giresunspor | 14 | 4 | 4 | 6 | 12:12 | 0 | 16 |
| 16 |
|
Kayserispor | 14 | 4 | 4 | 6 | 18:22 | -4 | 16 |
| 17 |
|
Yeni Malatyaspor | 14 | 4 | 1 | 9 | 12:23 | -11 | 13 |
| 18 |
|
Göztepe | 14 | 2 | 5 | 7 | 13:20 | -7 | 11 |
| 19 |
|
Kasımpaşa SK | 14 | 2 | 4 | 8 | 13:21 | -8 | 10 |
| 20 |
|
Çaykur Rizespor | 14 | 3 | 1 | 10 | 12:27 | -15 | 10 |
| Champions League | |
| CL Ronda previa | |
| ECL Ronda previa | |
| Descenso |
