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| 17.12.2021 | 18:00 | Giresunspor | - | Altay Izmir | 3:1 (1:0) | |
| 18.12.2021 | 11:30 | Kasımpaşa SK | - | Sivasspor | 1:3 (1:0) | |
| 14:00 | Konyaspor | - | Antalyaspor | 1:0 (0:0) | ||
| 14:00 | Trabzonspor | - | Hatayspor | 2:0 (2:0) | ||
| 17:00 | Alanyaspor | - | Adana Demirspor | 1:3 (1:2) | ||
| 17:00 | Galatasaray | - | İstanbul Başakşehir | 1:1 (0:1) | ||
| 19.12.2021 | 11:30 | Çaykur Rizespor | - | Yeni Malatyaspor | 1:0 (0:0) | |
| 14:00 | Göztepe | - | Fatih Karagümrük SK | 0:1 (0:0) | ||
| 14:00 | Kayserispor | - | Gaziantep FK | 0:0 (0:0) | ||
| 17:00 | Fenerbahçe | - | Beşiktaş | 2:2 (2:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Trabzonspor | 17 | 13 | 3 | 1 | 34:13 | 21 | 42 |
| 2 |
|
Konyaspor | 17 | 9 | 6 | 2 | 28:14 | 14 | 33 |
| 3 |
|
İstanbul Başakşehir | 17 | 9 | 2 | 6 | 26:18 | 8 | 29 |
| 4 |
|
Hatayspor | 17 | 9 | 2 | 6 | 25:20 | 5 | 29 |
| 5 |
|
Fenerbahçe | 17 | 8 | 4 | 5 | 28:22 | 6 | 28 |
| 6 |
|
Alanyaspor | 17 | 8 | 3 | 6 | 27:28 | -1 | 27 |
| 7 |
|
Adana Demirspor | 17 | 7 | 5 | 5 | 24:21 | 3 | 26 |
| 8 |
|
Sivasspor | 17 | 6 | 7 | 4 | 25:16 | 9 | 25 |
| 9 |
|
Beşiktaş | 17 | 7 | 4 | 6 | 28:26 | 2 | 25 |
| 10 |
|
Fatih Karagümrük SK | 17 | 7 | 4 | 6 | 24:25 | -1 | 25 |
| 11 |
|
Galatasaray | 17 | 6 | 6 | 5 | 22:21 | 1 | 24 |
| 12 |
|
Giresunspor | 17 | 6 | 4 | 7 | 18:15 | 3 | 22 |
| 13 |
|
Gaziantep FK | 17 | 6 | 4 | 7 | 21:25 | -4 | 22 |
| 14 |
|
Antalyaspor | 17 | 6 | 3 | 8 | 20:24 | -4 | 21 |
| 15 |
|
Kayserispor | 17 | 5 | 5 | 7 | 22:26 | -4 | 20 |
| 16 |
|
Altay Izmir | 17 | 5 | 3 | 9 | 22:28 | -6 | 18 |
| 17 |
|
Çaykur Rizespor | 17 | 5 | 1 | 11 | 16:32 | -16 | 16 |
| 18 |
|
Göztepe | 17 | 3 | 5 | 9 | 16:25 | -9 | 14 |
| 19 |
|
Yeni Malatyaspor | 17 | 4 | 2 | 11 | 14:30 | -16 | 14 |
| 20 |
|
Kasımpaşa SK | 17 | 2 | 5 | 10 | 16:27 | -11 | 11 |
| Champions League | |
| CL Ronda previa | |
| ECL Ronda previa | |
| Descenso |
