| 5. Jornada | 07.08.2021 | Unión de Santa Fe | - | San Lorenzo | 4:0 | ||||
| 8. Jornada | 26.08.2021 | Estudiantes | - | San Lorenzo | 2:0 | ||||
| 9. Jornada | 30.08.2021 | San Lorenzo | - | Patronato de Paraná | 3:0 | ||||
| 10. Jornada | 04.09.2021 | Platense | - | San Lorenzo | 1:1 | ||||
| 11. Jornada | 13.09.2021 | San Lorenzo | - | Racing Club | 1:1 | ||||
| 12. Jornada | 20.09.2021 | Rosario Central | - | San Lorenzo | 1:0 | ||||
| 13. Jornada | 26.09.2021 | San Lorenzo | - | Defensa y Justicia | 2:1 | ||||
| 15. Jornada | 11.10.2021 | San Lorenzo | - | Colón de Santa Fe | 1:2 | ||||
| 21. Jornada | 19.11.2021 | San Lorenzo | - | Gimnasia de La Plata | 0:1 | ||||
| 22. Jornada | 23.11.2021 | Aldosivi | - | San Lorenzo | 2:0 |
Argentina