| 1. Jornada | 11.09.2021 | Panetolikos | - | Asteras Tripolis | 0:0 | ||||
| 2. Jornada | 19.09.2021 | Asteras Tripolis | - | PAOK Saloniki | 0:1 | ||||
| 3. Jornada | 22.09.2021 | OFI Heraklion | - | Asteras Tripolis | 0:0 | ||||
| 4. Jornada | 26.09.2021 | Asteras Tripolis | - | Olympiacos | 0:2 |  |
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| 5. Jornada | 02.10.2021 | Volos NFC | - | Asteras Tripolis | 2:1 | ||||
| 9. Jornada | 07.11.2021 | Asteras Tripolis | - | Lamia | 0:1 | ||||
| 10. Jornada | 20.11.2021 | Ionikos Nikea | - | Asteras Tripolis | 1:1 | ||||
| 11. Jornada | 27.11.2021 | Asteras Tripolis | - | Atromitos | 6:2 | ||||
| 12. Jornada | 05.12.2021 | Aris Saloniki | - | Asteras Tripolis | 1:0 | ||||
| 13. Jornada | 11.12.2021 | Asteras Tripolis | - | AEK Athen | 0:0 | ||||
| 14. Jornada | 14.12.2021 | Asteras Tripolis | - | Panetolikos | 1:0 | ||||
| 15. Jornada | 19.12.2021 | PAOK Saloniki | - | Asteras Tripolis | 3:2 | ||||
| 19. Jornada | 24.01.2022 | Asteras Tripolis | - | Apollon Smyrnis | 1:0 | |
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| 23. Jornada | 12.02.2022 | Asteras Tripolis | - | Ionikos Nikea | 2:3 | ||||
| 22. Jornada | 23.02.2022 | Lamia | - | Asteras Tripolis | 0:2 | ||||
| 25. Jornada | 26.02.2022 | Asteras Tripolis | - | Aris Saloniki | 0:2 | ||||
| 17. Jornada | 02.03.2022 | Olympiacos | - | Asteras Tripolis | 5:1 |
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