| 9. Jornada | 18.09.2021 | Mazatlán FC [Sub 20] | - | Pumas UNAM [Sub 20] | 2:1 | ||||
| 10. Jornada | 25.09.2021 | Club Tijuana [Sub 20] | - | Mazatlán FC [Sub 20] | 3:5 |  |
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| 11. Jornada | 28.09.2021 | Mazatlán FC [Sub 20] | - | FC Juárez [Sub 20] | 2:2 | ||||
| 12. Jornada | 02.10.2021 | Santos Laguna [Sub 20] | - | Mazatlán FC [Sub 20] | 4:2 | ||||
| 13. Jornada | 15.10.2021 | Mazatlán FC [Sub 20] | - | Atlas Guadalajara [Sub 20] | 3:1 | ||||
| 14. Jornada | 19.10.2021 | Puebla FC [Sub 20] | - | Mazatlán FC [Sub 20] | 2:1 | ||||
| 15. Jornada | 22.10.2021 | Mazatlán FC [Sub 20] | - | Gallos Blancos [Sub 20] | 4:0 | |
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| 16. Jornada | 29.10.2021 | Club Necaxa [Sub 20] | - | Mazatlán FC [Sub 20] | 1:1 | ||||
| 17. Jornada | 05.11.2021 | Mazatlán FC [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 1:0 |
México