| 1. Jornada | 07.02.2022 | Nacional | - | Deportivo Maldonado | 2:3 | ||||
| 2. Jornada | 13.02.2022 | Rentistas | - | Nacional | 0:4 |  |
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| 3. Jornada | 22.02.2022 | Nacional | - | Liverpool | 0:0 | ||||
| 5. Jornada | 13.03.2022 | Nacional | - | Montevideo City Torque | 1:1 | ||||
| 8. Jornada | 10.04.2022 | Boston River | - | Nacional | 0:6 | ||||
| 9. Jornada | 17.04.2022 | Nacional | - | River Plate | 1:1 | |
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| 10. Jornada | 23.04.2022 | Cerro Largo | - | Nacional | 0:2 |
Uruguay