| 1. Jornada | 09.01.2022 | Pumas UNAM [Sub 18] | - | Deportivo Toluca [Sub 18] | 1:0 |  |
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| 3. Jornada | 23.01.2022 | Pumas UNAM [Sub 18] | - | UANL Tigres [Sub 18] | 1:4 | ||||
| 5. Jornada | 13.02.2022 | Pumas UNAM [Sub 18] | - | Club León [Sub 18] | 0:0 | ||||
| 6. Jornada | 20.02.2022 | Atlas Guadalajara [Sub 18] | - | Pumas UNAM [Sub 18] | 5:2 | ||||
| 8. Jornada | 02.03.2022 | Santos Laguna [Sub 18] | - | Pumas UNAM [Sub 18] | 0:0 | ||||
| 11. Jornada | 19.03.2022 | Pumas UNAM [Sub 18] | - | Club Necaxa [Sub 18] | 0:0 | ||||
| 9. Jornada | 26.03.2022 | Pumas UNAM [Sub 18] | - | Mazatlán FC [Sub 18] | 3:0 | ||||
| 13. Jornada | 08.04.2022 | Puebla FC [Sub 18] | - | Pumas UNAM [Sub 18] | 2:4 | ||||
| 16. Jornada | 23.04.2022 | Deportivo Guadalajara [Sub 18] | - | Pumas UNAM [Sub 18] | 1:2 | ||||
| 17. Jornada | 01.05.2022 | Pumas UNAM [Sub 18] | - | CF Pachuca [Sub 18] | 0:1 |
México