| 3. Jornada | 11.09.2016 | AEK Athen | - | Xanthi FC | 4:1 | ||||
| 4. Jornada | 17.09.2016 | Xanthi FC | - | Panionios GSS | 0:2 |  |
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| 5. Jornada | 25.09.2016 | PAOK Saloniki | - | Xanthi FC | 0:0 | |
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| 6. Jornada | 03.10.2016 | Xanthi FC | - | Atromitos | 0:0 | ||||
| 7. Jornada | 16.10.2016 | Panathinaikos | - | Xanthi FC | 1:2 | |
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| 8. Jornada | 22.10.2016 | Platanias Chanion | - | Xanthi FC | 0:1 | ||||
| 9. Jornada | 29.10.2016 | Xanthi FC | - | AO Kerkyra | 0:0 | ||||
| 10. Jornada | 05.11.2016 | Levadiakos | - | Xanthi FC | 1:1 | |
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| 13. Jornada | 04.12.2016 | Xanthi FC | - | Asteras Tripolis | 3:1 | ||||
| 14. Jornada | 10.12.2016 | Xanthi FC | - | AE Lárissa | 1:0 | ||||
| 15. Jornada | 17.12.2016 | Veria FC | - | Xanthi FC | 0:4 | ||||
| 2. Jornada | 08.01.2017 | Xanthi FC | - | Olympiacos | 0:2 |
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