| 1. Jornada | 16.08.2021 | FC Cartagena | - | Almería | 1:3 |  |
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| 2. Jornada | 22.08.2021 | Huesca | - | FC Cartagena | 2:0 | ||||
| 3. Jornada | 30.08.2021 | Zaragoza | - | FC Cartagena | 0:1 | ||||
| 4. Jornada | 04.09.2021 | FC Cartagena | - | Real Sociedad B | 1:0 | ||||
| 5. Jornada | 12.09.2021 | Real Oviedo | - | FC Cartagena | 2:0 | |
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| 6. Jornada | 18.09.2021 | FC Cartagena | - | Lugo | 2:1 | |
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| 7. Jornada | 27.09.2021 | CF Fuenlabrada | - | FC Cartagena | 2:1 | ||||
| 8. Jornada | 03.10.2021 | Las Palmas | - | FC Cartagena | 4:1 | |
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| 9. Jornada | 10.10.2021 | FC Cartagena | - | UD Ibiza | 5:1 | |
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| 11. Jornada | 19.10.2021 | FC Cartagena | - | Sporting | 1:0 | ||||
| 13. Jornada | 30.10.2021 | FC Cartagena | - | Ponferradina | 0:1 | ||||
| 14. Jornada | 02.11.2021 | Leganés | - | FC Cartagena | 1:1 | |
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| 15. Jornada | 07.11.2021 | FC Cartagena | - | Málaga | 3:1 | |
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| 16. Jornada | 14.11.2021 | Girona | - | FC Cartagena | 2:0 | |
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| 17. Jornada | 21.11.2021 | FC Cartagena | - | Burgos CF | 1:0 | |
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| 18. Jornada | 27.11.2021 | Valladolid | - | FC Cartagena | 2:0 |
España