| 1. Jornada | 05.09.2021 | CS Puertollano CF | - | CA Pulpileño | 2:0 | ||||
| 2. Jornada | 12.09.2021 | Atlético Mancha Real | - | CS Puertollano CF | 2:0 | ||||
| 3. Jornada | 19.09.2021 | CS Puertollano CF | - | Atlético Levante | 0:0 | ||||
| 4. Jornada | 26.09.2021 | CD Toledo | - | CS Puertollano CF | 1:4 |  |
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| 5. Jornada | 03.10.2021 | CS Puertollano CF | - | CD El Ejido 2012 | 1:1 | ||||
| 6. Jornada | 10.10.2021 | CD Marchamalo | - | CS Puertollano CF | 0:0 | ||||
| 7. Jornada | 17.10.2021 | CS Puertollano CF | - | CF La Nucía | 1:2 |  |
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| 8. Jornada | 24.10.2021 | Granada B | - | CS Puertollano CF | 2:1 | |
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| 9. Jornada | 31.10.2021 | CS Puertollano CF | - | CD Eldense | 0:1 | ||||
| 11. Jornada | 14.11.2021 | CS Puertollano CF | - | Hércules CF | 2:1 | ||||
| 12. Jornada | 21.11.2021 | Mar Menor CF | - | CS Puertollano CF | 1:0 | ||||
| 13. Jornada | 28.11.2021 | CS Puertollano CF | - | Real Murcia | 1:2 | ||||
| 14. Jornada | 05.12.2021 | UD Alzira | - | CS Puertollano CF | 2:1 | ||||
| 15. Jornada | 12.12.2021 | CS Puertollano CF | - | UD Melilla | 1:0 | ||||
| 16. Jornada | 19.12.2021 | CS Puertollano CF | - | UD Socuéllamos | 1:1 |
España