| 19. Jornada | 22.01.2022 | CyD Leonesa | - | Real Unión | 1:1 |  |
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| 21. Jornada | 29.01.2022 | CyD Leonesa | - | CD Badajoz | 1:0 |  |
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| 23. Jornada | 13.02.2022 | CyD Leonesa | - | Unionistas CF | 0:1 | ||||
| 24. Jornada | 19.02.2022 | Extremadura UD | - | CyD Leonesa | 1:3 | ||||
| 25. Jornada | 26.02.2022 | CyD Leonesa | - | CD Tudelano | 3:1 | ||||
| 26. Jornada | 04.03.2022 | Rayo Majadahonda | - | CyD Leonesa | 1:0 | ||||
| 22. Jornada | 09.03.2022 | Real Racing | - | CyD Leonesa | 4:0 | ||||
| 27. Jornada | 13.03.2022 | CyD Leonesa | - | SD Logroñés | 2:2 | |
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| 28. Jornada | 19.03.2022 | Deportivo | - | CyD Leonesa | 2:1 |  |
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| 32. Jornada | 17.04.2022 | UD SS Reyes | - | CyD Leonesa | 0:3 | ||||
| 34. Jornada | 01.05.2022 | CyD Leonesa | - | Zamora CF | 0:0 | ||||
| 35. Jornada | 08.05.2022 | Celta B | - | CyD Leonesa | 5:3 |
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