| 1. Jornada | 24.07.2021 | CF Pachuca | - | Club León | 4:0 | ||||
| 2. Jornada | 31.07.2021 | Mazatlán FC | - | CF Pachuca | 2:1 | ||||
| 3. Jornada | 10.08.2021 | CF Pachuca | - | Atlas Guadalajara | 0:1 | ||||
| 4. Jornada | 15.08.2021 | CF Monterrey | - | CF Pachuca | 3:1 | ||||
| 9. Jornada | 19.09.2021 | Deportivo Guadalajara | - | CF Pachuca | 1:0 | ||||
| 10. Jornada | 24.09.2021 | CF Pachuca | - | Club Necaxa | 1:0 | ||||
| 11. Jornada | 29.09.2021 | CF Pachuca | - | CF América | 1:1 | ||||
| 13. Jornada | 17.10.2021 | CF Pachuca | - | Santos Laguna | 1:1 | ||||
| 14. Jornada | 21.10.2021 | UANL Tigres | - | CF Pachuca | 3:0 | ||||
| 15. Jornada | 25.10.2021 | CF Pachuca | - | FC Juárez | 1:1 | ||||
| 16. Jornada | 31.10.2021 | CF Pachuca | - | Pumas UNAM | 1:1 | ||||
| 17. Jornada | 07.11.2021 | Club Tijuana | - | CF Pachuca | 3:2 |
Colombia