| 5. Jornada | 25.09.2021 | CyD Leonesa | - | Valladolid B | 4:2 | ||||
| 8. Jornada | 16.10.2021 | CyD Leonesa | - | Extremadura UD | 2:1 | ||||
| 11. Jornada | 07.11.2021 | CyD Leonesa | - | Real Racing | 3:0 | ||||
| 12. Jornada | 12.11.2021 | SD Logroñés | - | CyD Leonesa | 1:1 | ||||
| 13. Jornada | 20.11.2021 | CyD Leonesa | - | UD SS Reyes | 2:0 | ||||
| 14. Jornada | 28.11.2021 | CD Calahorra | - | CyD Leonesa | 2:0 | ||||
| 15. Jornada | 05.12.2021 | CyD Leonesa | - | Celta B | 0:1 |  |
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| 16. Jornada | 11.12.2021 | Zamora CF | - | CyD Leonesa | 2:2 |
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