| 4. Jornada | 26.09.2021 | CD Toledo | - | CS Puertollano CF | 1:4 | ||||
| 6. Jornada | 10.10.2021 | CD Marchamalo | - | CS Puertollano CF | 0:0 | ||||
| 8. Jornada | 24.10.2021 | Granada B | - | CS Puertollano CF | 2:1 | ||||
| 9. Jornada | 31.10.2021 | CS Puertollano CF | - | CD Eldense | 0:1 | ||||
| 15. Jornada | 12.12.2021 | CS Puertollano CF | - | UD Melilla | 1:0 | ||||
| 17. Jornada | 09.01.2022 | Águilas FC | - | CS Puertollano CF | 1:0 |  |
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| 20. Jornada | 05.02.2022 | Atlético Levante | - | CS Puertollano CF | 0:0 | ||||
| 25. Jornada | 13.03.2022 | CS Puertollano CF | - | Granada B | 3:0 | |
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| 26. Jornada | 20.03.2022 | CD Eldense | - | CS Puertollano CF | 3:2 |
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