| 6. Jornada | 22.08.2021 | Pumas UNAM [Sub 20] | - | Puebla FC [Sub 20] | 1:3 | ||||
| 7. Jornada | 29.08.2021 | Deportivo Toluca [Sub 20] | - | Pumas UNAM [Sub 20] | 2:2 | ||||
| 8. Jornada | 12.09.2021 | Pumas UNAM [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 1:2 | ||||
| 9. Jornada | 18.09.2021 | Mazatlán FC [Sub 20] | - | Pumas UNAM [Sub 20] | 2:1 | ||||
| 10. Jornada | 25.09.2021 | UANL Tigres [Sub 20] | - | Pumas UNAM [Sub 20] | 2:1 | ||||
| 12. Jornada | 03.10.2021 | CF América [Sub 20] | - | Pumas UNAM [Sub 20] | 0:0 | ||||
| 13. Jornada | 17.10.2021 | Pumas UNAM [Sub 20] | - | FC Juárez [Sub 20] | 3:0 | ||||
| 15. Jornada | 24.10.2021 | Pumas UNAM [Sub 20] | - | Club Tijuana [Sub 20] | 4:0 | ||||
| 16. Jornada | 30.10.2021 | CF Pachuca [Sub 20] | - | Pumas UNAM [Sub 20] | 1:0 | ||||
| 11. Jornada | 04.11.2021 | Pumas UNAM [Sub 20] | - | Santos Laguna [Sub 20] | 2:1 | ||||
| 17. Jornada | 07.11.2021 | Pumas UNAM [Sub 20] | - | Cruz Azul [Sub 20] | 1:2 |  |
México