| 3. Jornada | 12.09.2021 | Unionistas CF | - | Extremadura UD | 3:0 | ||||
| 8. Jornada | 16.10.2021 | CyD Leonesa | - | Extremadura UD | 2:1 |  |
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| 9. Jornada | 22.10.2021 | Extremadura UD | - | CD Tudelano | 1:1 |  |
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| 11. Jornada | 07.11.2021 | Extremadura UD | - | Inter de Madrid | 1:2 | ||||
| 14. Jornada | 28.11.2021 | Celta B | - | Extremadura UD | 1:1 | ||||
| 16. Jornada | 12.12.2021 | UD Logroñés | - | Extremadura UD | 1:3 | ||||
| 17. Jornada | 18.12.2021 | Extremadura UD | - | Real Racing | 2:4 | |
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| 18. Jornada | 08.01.2022 | Real Unión | - | Extremadura UD | 0:1 |
España