| 1. Jornada | 08.08.2021 | Atlético Chiriquí | - | San Francisco FC | 1:1 | ||||
| 2. Jornada | 14.08.2021 | San Francisco FC | - | UD Universitario | 0:1 | ||||
| 3. Jornada | 22.08.2021 | Independiente de La Chorrera | - | San Francisco FC | 2:0 | ||||
| 4. Jornada | 28.08.2021 | San Francisco FC | - | Herrera FC | 1:3 | ||||
| 5. Jornada | 05.09.2021 | Veraguas Club Deportivo | - | San Francisco FC | 1:0 | ||||
| 7. Jornada | 19.09.2021 | Plaza Amador | - | San Francisco FC | 1:1 | ||||
| 8. Jornada | 27.09.2021 | Deportivo del Este | - | San Francisco FC | 0:0 | ||||
| 9. Jornada | 02.10.2021 | San Francisco FC | - | Alianza | 0:1 | ||||
| 10. Jornada | 10.10.2021 | Sporting San Miguelito | - | San Francisco FC | 1:1 | ||||
| 11. Jornada | 16.10.2021 | San Francisco FC | - | Árabe Unido | 1:0 | ||||
| 12. Jornada | 23.10.2021 | San Francisco FC | - | Atlético Chiriquí | 1:0 | ||||
| 13. Jornada | 30.10.2021 | UD Universitario | - | San Francisco FC | 0:1 | ||||
| 14. Jornada | 06.11.2021 | San Francisco FC | - | Independiente de La Chorrera | 1:1 | ||||
| 15. Jornada | 13.11.2021 | Herrera FC | - | San Francisco FC | 2:1 | ||||
| 16. Jornada | 20.11.2021 | San Francisco FC | - | Veraguas Club Deportivo | 0:1 |
Panamá