| 8. Jornada | 10.09.2021 | Puebla FC [Sub 20] | - | Atlético San Luis [Sub 20] | 2:2 | ||||
| 11. Jornada | 28.09.2021 | Atlas Guadalajara [Sub 20] | - | Puebla FC [Sub 20] | 3:3 | ||||
| 13. Jornada | 15.10.2021 | Club Necaxa [Sub 20] | - | Puebla FC [Sub 20] | 1:1 | ||||
| 14. Jornada | 19.10.2021 | Puebla FC [Sub 20] | - | Mazatlán FC [Sub 20] | 2:1 | ||||
| 15. Jornada | 23.10.2021 | Puebla FC [Sub 20] | - | Club León [Sub 20] | 2:1 | ||||
| 16. Jornada | 29.10.2021 | FC Juárez [Sub 20] | - | Puebla FC [Sub 20] | 1:1 |
México