| 1. Jornada | 26.07.2021 | Cruz Azul [Sub 20] | - | Mazatlán FC [Sub 20] | 1:1 | ||||
| 4. Jornada | 14.08.2021 | Club León [Sub 20] | - | Mazatlán FC [Sub 20] | 1:0 | ||||
| 5. Jornada | 17.08.2021 | Deportivo Toluca [Sub 20] | - | Mazatlán FC [Sub 20] | 3:1 | ||||
| 8. Jornada | 11.09.2021 | CF América [Sub 20] | - | Mazatlán FC [Sub 20] | 3:0 | ||||
| 10. Jornada | 25.09.2021 | Club Tijuana [Sub 20] | - | Mazatlán FC [Sub 20] | 3:5 | ||||
| 11. Jornada | 28.09.2021 | Mazatlán FC [Sub 20] | - | FC Juárez [Sub 20] | 2:2 | ||||
| 13. Jornada | 15.10.2021 | Mazatlán FC [Sub 20] | - | Atlas Guadalajara [Sub 20] | 3:1 |  |
México