| 2. Jornada | 11.08.2021 | Marathón | - | Lobos UPNFM | 5:1 |  |
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| 3. Jornada | 14.08.2021 | Marathón | - | Motagua | 2:0 | ||||
| 4. Jornada | 22.08.2021 | Vida | - | Marathón | 2:0 |  |
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| 8. Jornada | 12.09.2021 | Victoria | - | Marathón | 1:0 | ||||
| 11. Jornada | 25.09.2021 | Marathón | - | Vida | 1:2 | |
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| 12. Jornada | 04.10.2021 | Lobos UPNFM | - | Marathón | 1:1 | ||||
| 15. Jornada | 24.10.2021 | Marathón | - | Platense | 1:1 | ||||
| 16. Jornada | 28.10.2021 | Olimpia | - | Marathón | 1:0 |
Honduras