| 3. Jornada | 20.02.2022 | General Caballero DJLM | - | Tacuary | 2:0 |  |
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| 4. Jornada | 28.02.2022 | Tacuary | - | Libertad | 0:1 | |
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| 5. Jornada | 07.03.2022 | Club Olimpia | - | Tacuary | 2:0 | |
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| 6. Jornada | 11.03.2022 | Sportivo Ameliano | - | Tacuary | 0:2 | ||||
| 7. Jornada | 21.03.2022 | Tacuary | - | Club Nacional | 2:1 | ||||
| 8. Jornada | 04.04.2022 | Guaraní | - | Tacuary | 1:2 | ||||
| 9. Jornada | 11.04.2022 | Tacuary | - | Guaireña FC | 0:1 | ||||
| 10. Jornada | 19.04.2022 | Sol de América | - | Tacuary | 1:0 | |
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| 12. Jornada | 26.04.2022 | Tacuary | - | Resistencia SC | 3:1 | ||||
| 13. Jornada | 30.04.2022 | 12 de Octubre de Itauguá | - | Tacuary | 2:0 | ||||
| 14. Jornada | 07.05.2022 | Tacuary | - | General Caballero DJLM | 0:0 | ||||
| 15. Jornada | 11.05.2022 | Libertad | - | Tacuary | 3:0 | ||||
| 16. Jornada | 16.05.2022 | Tacuary | - | Club Olimpia | 1:4 | ||||
| 17. Jornada | 20.05.2022 | Tacuary | - | Sportivo Ameliano | 1:0 | ||||
| 18. Jornada | 13.06.2022 | Club Nacional | - | Tacuary | 3:0 | |
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| 20. Jornada | 24.06.2022 | Guaireña FC | - | Tacuary | 0:0 | ||||
| 21. Jornada | 28.06.2022 | Tacuary | - | Sol de América | 2:2 | ||||
| 22. Jornada | 02.07.2022 | Cerro Porteño | - | Tacuary | 1:0 |
Paraguay