| 1. Jornada | 27.08.2021 | CyD Leonesa | - | Rayo Majadahonda | 0:2 | ||||
| 2. Jornada | 05.09.2021 | Unionistas CF | - | CyD Leonesa | 2:2 | ||||
| 3. Jornada | 12.09.2021 | CyD Leonesa | - | Bilbao Athletic | 2:1 |  |
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| 4. Jornada | 19.09.2021 | Inter de Madrid | - | CyD Leonesa | 3:2 | ||||
| 6. Jornada | 02.10.2021 | CD Badajoz | - | CyD Leonesa | 3:3 | ||||
| 7. Jornada | 09.10.2021 | CyD Leonesa | - | CF Talavera | 1:2 | ||||
| 8. Jornada | 16.10.2021 | CyD Leonesa | - | Extremadura UD | 2:1 | |
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| 9. Jornada | 23.10.2021 | Racing de Ferrol | - | CyD Leonesa | 1:1 | |
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| 10. Jornada | 30.10.2021 | CD Tudelano | - | CyD Leonesa | 1:1 | ||||
| 11. Jornada | 07.11.2021 | CyD Leonesa | - | Real Racing | 3:0 | |
España