| 3. Jornada | 18.09.2021 | UD Melilla | - | Granada B | 1:3 |  |
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| 4. Jornada | 26.09.2021 | CF Intercity | - | UD Melilla | 0:0 | |
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| 5. Jornada | 03.10.2021 | UD Melilla | - | Mar Menor CF | 2:3 | ||||
| 6. Jornada | 10.10.2021 | UD Alzira | - | UD Melilla | 0:1 | ||||
| 7. Jornada | 17.10.2021 | UD Melilla | - | UD Socuéllamos | 3:1 | |
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| 8. Jornada | 24.10.2021 | CA Pulpileño | - | UD Melilla | 1:3 | ||||
| 9. Jornada | 31.10.2021 | UD Melilla | - | Atlético Levante | 1:0 | |
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| 10. Jornada | 07.11.2021 | CD El Ejido 2012 | - | UD Melilla | 3:1 | |
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| 13. Jornada | 28.11.2021 | UD Melilla | - | Hércules CF | 1:2 |  |
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| 15. Jornada | 12.12.2021 | CS Puertollano CF | - | UD Melilla | 1:0 |  |
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