| 1. Jornada | 29.08.2021 | Zamora CF | - | Bilbao Athletic | 0:1 |  |
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| 2. Jornada | 05.09.2021 | Bilbao Athletic | - | Racing de Ferrol | 2:2 | ||||
| 3. Jornada | 12.09.2021 | CyD Leonesa | - | Bilbao Athletic | 2:1 | ||||
| 4. Jornada | 17.09.2021 | Bilbao Athletic | - | Unionistas CF | 0:1 | ||||
| 5. Jornada | 26.09.2021 | Bilbao Athletic | - | UD Logroñés | 3:1 | ||||
| 6. Jornada | 03.10.2021 | CD Tudelano | - | Bilbao Athletic | 2:2 | ||||
| 7. Jornada | 08.10.2021 | Bilbao Athletic | - | Celta B | 0:1 | ||||
| 8. Jornada | 17.10.2021 | Valladolid B | - | Bilbao Athletic | 3:1 | |
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| 9. Jornada | 23.10.2021 | Bilbao Athletic | - | Real Unión | 0:0 | ||||
| 11. Jornada | 07.11.2021 | Bilbao Athletic | - | Rayo Majadahonda | 1:1 | |
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| 13. Jornada | 21.11.2021 | Bilbao Athletic | - | CF Talavera | 0:1 | ||||
| 14. Jornada | 28.11.2021 | Deportivo | - | Bilbao Athletic | 1:1 | ||||
| 15. Jornada | 05.12.2021 | Bilbao Athletic | - | CD Badajoz | 0:0 |  |
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| 17. Jornada | 19.12.2021 | Bilbao Athletic | - | UD SS Reyes | 0:2 | ||||
| 21. Jornada | 29.01.2022 | Celta B | - | Bilbao Athletic | 4:1 | ||||
| 36. Jornada | 15.05.2022 | Racing de Ferrol | - | Bilbao Athletic | 1:1 |
España