| 1. Jornada | 16.07.2021 | River Plate II | - | Colón de Santa Fe II | 1:2 | ||||
| 2. Jornada | 23.07.2021 | River Plate II | - | Unión de Santa Fe II | 2:0 | ||||
| 3. Jornada | 27.07.2021 | Lanús II | - | River Plate II | 0:1 | ||||
| 4. Jornada | 30.07.2021 | River Plate II | - | Huracán II | 2:0 | ||||
| 5. Jornada | 06.08.2021 | Godoy Cruz II | - | River Plate II | 0:1 | ||||
| 6. Jornada | 13.08.2021 | River Plate II | - | Vélez Sarsfield II | 1:2 | ||||
| 7. Jornada | 19.08.2021 | Gimnasia de La Plata II | - | River Plate II | 3:1 | ||||
| 8. Jornada | 23.08.2021 | River Plate II | - | Aldosivi II | 3:0 | ||||
| 9. Jornada | 31.08.2021 | Sarmiento de Junín II | - | River Plate II | 3:1 | ||||
| 10. Jornada | 06.09.2021 | River Plate II | - | Independiente II | 4:0 | ||||
| 11. Jornada | 10.09.2021 | Newell's Old Boys II | - | River Plate II | 0:2 | ||||
| 12. Jornada | 17.09.2021 | River Plate II | - | Arsenal de Sarandí II | 0:1 | ||||
| 13. Jornada | 24.09.2021 | Central Córdoba SdE II | - | River Plate II | 1:2 | ||||
| 15. Jornada | 07.10.2021 | Banfield II | - | River Plate II | 2:0 | ||||
| 23. Jornada | 28.11.2021 | Rosario Central II | - | River Plate II | 2:0 |
Argentina