| 2. Jornada | 05.09.2021 | Unionistas CF | - | CyD Leonesa | 2:2 |  |
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| 3. Jornada | 12.09.2021 | CyD Leonesa | - | Bilbao Athletic | 2:1 | ||||
| 5. Jornada | 25.09.2021 | CyD Leonesa | - | Valladolid B | 4:2 | ||||
| 10. Jornada | 30.10.2021 | CD Tudelano | - | CyD Leonesa | 1:1 | ||||
| 11. Jornada | 07.11.2021 | CyD Leonesa | - | Real Racing | 3:0 | ||||
| 12. Jornada | 12.11.2021 | SD Logroñés | - | CyD Leonesa | 1:1 |  |
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| 13. Jornada | 20.11.2021 | CyD Leonesa | - | UD SS Reyes | 2:0 | |
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| 14. Jornada | 28.11.2021 | CD Calahorra | - | CyD Leonesa | 2:0 | ||||
| 15. Jornada | 05.12.2021 | CyD Leonesa | - | Celta B | 0:1 | ||||
| 16. Jornada | 11.12.2021 | Zamora CF | - | CyD Leonesa | 2:2 | ||||
| 19. Jornada | 22.01.2022 | CyD Leonesa | - | Real Unión | 1:1 | |
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| 20. Jornada | 25.01.2022 | Bilbao Athletic | - | CyD Leonesa | 1:2 | |
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| 21. Jornada | 29.01.2022 | CyD Leonesa | - | CD Badajoz | 1:0 | |
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| 22. Jornada | 09.03.2022 | Real Racing | - | CyD Leonesa | 4:0 | |
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| 35. Jornada | 08.05.2022 | Celta B | - | CyD Leonesa | 5:3 | |
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