| 1. Jornada | 05.02.2022 | Club Olimpia | - | General Caballero DJLM | 2:2 | ||||
| 2. Jornada | 12.02.2022 | Guaireña FC | - | Club Olimpia | 1:3 | ||||
| 3. Jornada | 21.02.2022 | Club Olimpia | - | Libertad | 2:2 | ||||
| 5. Jornada | 07.03.2022 | Club Olimpia | - | Tacuary | 2:0 | ||||
| 7. Jornada | 21.03.2022 | Club Olimpia | - | Sportivo Ameliano | 0:2 | ||||
| 9. Jornada | 09.04.2022 | Club Olimpia | - | Club Nacional | 1:2 | ||||
| 13. Jornada | 02.05.2022 | Club Olimpia | - | Guaireña FC | 1:0 | ||||
| 16. Jornada | 16.05.2022 | Tacuary | - | Club Olimpia | 1:4 | ||||
| 17. Jornada | 22.05.2022 | Club Olimpia | - | Cerro Porteño | 0:4 | ||||
| 18. Jornada | 14.06.2022 | Sportivo Ameliano | - | Club Olimpia | 1:4 | ||||
| 21. Jornada | 26.06.2022 | Club Olimpia | - | 12 de Octubre de Itauguá | 4:1 | ||||
| 22. Jornada | 04.07.2022 | Guaraní | - | Club Olimpia | 0:2 |
Argentina