| 1. Jornada | 29.08.2021 | UD SS Reyes | - | Extremadura UD | 1:0 | ||||
| 2. Jornada | 04.09.2021 | Extremadura UD | - | SD Logroñés | 0:0 | ||||
| 4. Jornada | 17.09.2021 | Extremadura UD | - | Racing de Ferrol | 1:0 | ||||
| 5. Jornada | 26.09.2021 | Extremadura UD | - | Rayo Majadahonda | 3:2 | ||||
| 6. Jornada | 03.10.2021 | CF Talavera | - | Extremadura UD | 1:1 | ||||
| 7. Jornada | 09.10.2021 | Extremadura UD | - | Valladolid B | 1:0 | ||||
| 8. Jornada | 16.10.2021 | CyD Leonesa | - | Extremadura UD | 2:1 | ||||
| 9. Jornada | 22.10.2021 | Extremadura UD | - | CD Tudelano | 1:1 | ||||
| 10. Jornada | 30.10.2021 | CD Badajoz | - | Extremadura UD | 2:0 | ||||
| 11. Jornada | 07.11.2021 | Extremadura UD | - | Inter de Madrid | 1:2 |  |
España