| 8. Jornada | 26.02.2022 | CF América [Sub 16] | - | Deportivo Toluca [Sub 16] | 0:4 | ||||
| 11. Jornada | 19.03.2022 | Pumas UNAM [Sub 16] | - | CF América [Sub 16] | 1:0 | ||||
| 13. Jornada | 03.04.2022 | Club Necaxa [Sub 16] | - | CF América [Sub 16] | 2:1 | ||||
| 15. Jornada | 16.04.2022 | Deportivo Toluca [Sub 16] | - | CF América [Sub 16] | 1:2 | ||||
| 16. Jornada | 23.04.2022 | CF América [Sub 16] | - | CF Pachuca [Sub 16] | 2:0 |  |
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| 14. Jornada | 27.04.2022 | CF América [Sub 16] | - | Cruz Azul [Sub 16] | 1:0 | ||||
| 17. Jornada | 30.04.2022 | Puebla FC [Sub 16] | - | CF América [Sub 16] | 1:2 | |
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| 18. Jornada | 07.05.2022 | CF América [Sub 16] | - | FC Juárez [Sub 16] | 3:3 |
México