| 1. Jornada | 29.08.2021 | UD SS Reyes | - | Extremadura UD | 1:0 |  |
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| 5. Jornada | 26.09.2021 | Extremadura UD | - | Rayo Majadahonda | 3:2 |  |
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| 7. Jornada | 09.10.2021 | Extremadura UD | - | Valladolid B | 1:0 | ||||
| 8. Jornada | 16.10.2021 | CyD Leonesa | - | Extremadura UD | 2:1 | ||||
| 10. Jornada | 30.10.2021 | CD Badajoz | - | Extremadura UD | 2:0 | |
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| 11. Jornada | 07.11.2021 | Extremadura UD | - | Inter de Madrid | 1:2 | ||||
| 13. Jornada | 20.11.2021 | Extremadura UD | - | CD Calahorra | 0:2 | ||||
| 14. Jornada | 28.11.2021 | Celta B | - | Extremadura UD | 1:1 | ||||
| 15. Jornada | 04.12.2021 | Extremadura UD | - | Zamora CF | 2:2 |
España