| 20. Jornada | 05.02.2022 | Atlético Levante | - | CS Puertollano CF | 0:0 |  |
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| 22. Jornada | 20.02.2022 | CD El Ejido 2012 | - | CS Puertollano CF | 2:0 | ||||
| 24. Jornada | 06.03.2022 | CF La Nucía | - | CS Puertollano CF | 3:2 | ||||
| 25. Jornada | 13.03.2022 | CS Puertollano CF | - | Granada B | 3:0 | ||||
| 26. Jornada | 20.03.2022 | CD Eldense | - | CS Puertollano CF | 3:2 | ||||
| 27. Jornada | 27.03.2022 | CS Puertollano CF | - | CF Intercity | 0:1 | ||||
| 31. Jornada | 24.04.2022 | CS Puertollano CF | - | UD Alzira | 1:3 | ||||
| 32. Jornada | 01.05.2022 | UD Melilla | - | CS Puertollano CF | 2:1 | ||||
| 33. Jornada | 08.05.2022 | UD Socuéllamos | - | CS Puertollano CF | 2:3 | ||||
| 34. Jornada | 15.05.2022 | CS Puertollano CF | - | Águilas FC | 1:2 |
Venezuela