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| 08.07.2022 | 23:10 | Nueva Chicago | - | Belgrano | 0:1 (0:0) | |
| 09.07.2022 | 01:10 | Ferro Carril Oeste | - | Gimnasia de Mendoza | 0:0 (0:0) | |
| 20:00 | Almagro | - | Villa Dálmine | 1:0 (1:0) | ||
| 20:00 | Brown de Adrogué | - | Guillermo Brown | 2:0 (0:0) | ||
| 20:00 | Tristan Suárez | - | Estudiantes de Caseros | 2:0 (1:0) | ||
| 20:30 | Deportivo Maipú | - | Deportivo Riestra | 2:2 (2:2) | ||
| 23:00 | Agropecuario Argentino | - | Atlanta | 1:0 (0:0) | ||
| 10.07.2022 | 00:10 | Independiente Rivadavia | - | All Boys | 1:1 (0:1) | |
| 01:10 | Quilmes | - | Güemes de SdE | 0:2 (0:1) | ||
| 02:10 | Deportivo Morón | - | Temperley | 1:1 (0:1) | ||
| 20:00 | Deportivo Madryn | - | Flandria | 3:2 (0:2) | ||
| 20:00 | Instituto de Córdoba | - | San Martín de San Juan | 2:1 (1:1) | ||
| 20:00 | Sacachispas | - | Chaco For Ever | 0:1 (0:1) | ||
| 21:00 | Mitre de SdE | - | San Telmo | 2:1 (2:0) | ||
| 21:00 | Estudiantes de Río Cuarto | - | Gimnasia de Jujuy | 3:1 (1:1) | ||
| 11.07.2022 | 22:35 | Defensores de Belgrano | - | Atlético Rafaela | 1:1 (1:1) | |
| 12.07.2022 | 00:40 | Alvarado | - | Almirante Brown | 0:2 (0:1) | |
| 02:40 | San Martín de Tucumán | - | Ramón Santamarina | 4:0 (2:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano | 22 | 16 | 4 | 2 | 28:12 | 16 | 52 |
| 2 |
|
San Martín de Tucumán | 22 | 12 | 8 | 2 | 30:15 | 15 | 44 |
| 3 |
|
Instituto de Córdoba | 22 | 11 | 8 | 3 | 27:15 | 12 | 41 |
| 4 |
|
All Boys | 22 | 9 | 12 | 1 | 32:17 | 15 | 39 |
| 5 |
|
Brown de Adrogué | 22 | 10 | 8 | 4 | 29:20 | 9 | 38 |
| 6 |
|
Gimnasia de Mendoza | 22 | 9 | 9 | 4 | 25:12 | 13 | 36 |
| 7 |
|
Estudiantes de Río Cuarto | 23 | 9 | 9 | 5 | 27:23 | 4 | 36 |
| 8 |
|
San Martín de San Juan | 23 | 10 | 5 | 8 | 32:23 | 9 | 35 |
| 9 |
|
Almagro | 23 | 10 | 5 | 8 | 21:22 | -1 | 35 |
| 10 |
|
Deportivo Madryn | 23 | 8 | 10 | 5 | 32:24 | 8 | 34 |
| 11 |
|
Independiente Rivadavia | 22 | 9 | 6 | 7 | 30:23 | 7 | 33 |
| 12 |
|
Chaco For Ever | 23 | 7 | 12 | 4 | 25:18 | 7 | 33 |
| 13 |
|
Deportivo Riestra | 22 | 7 | 11 | 4 | 21:17 | 4 | 32 |
| 14 |
|
Chacarita Juniors | 22 | 8 | 7 | 7 | 33:29 | 4 | 31 |
| 15 |
|
Defensores de Belgrano | 22 | 7 | 10 | 5 | 24:20 | 4 | 31 |
| 16 |
|
Deportivo Maipú | 23 | 6 | 13 | 4 | 24:21 | 3 | 31 |
| 17 |
|
Estudiantes de Caseros | 23 | 8 | 7 | 8 | 20:21 | -1 | 31 |
| 18 |
|
Guillermo Brown | 23 | 9 | 4 | 10 | 20:23 | -3 | 31 |
| 19 |
|
Agropecuario Argentino | 22 | 6 | 11 | 5 | 22:19 | 3 | 29 |
| 20 |
|
Güemes de SdE | 22 | 7 | 7 | 8 | 19:18 | 1 | 28 |
| 21 |
|
Ferro Carril Oeste | 22 | 6 | 9 | 7 | 18:22 | -4 | 27 |
| 22 |
|
Quilmes | 22 | 6 | 8 | 8 | 27:29 | -2 | 26 |
| 23 |
|
Gimnasia de Jujuy | 22 | 6 | 8 | 8 | 22:27 | -5 | 26 |
| 24 |
|
Deportivo Morón | 23 | 4 | 13 | 6 | 14:14 | 0 | 25 |
| 25 |
|
Mitre de SdE | 22 | 6 | 7 | 9 | 23:24 | -1 | 25 |
| 26 |
|
Almirante Brown | 22 | 5 | 10 | 7 | 24:28 | -4 | 25 |
| 27 |
|
Alvarado | 23 | 6 | 7 | 10 | 21:35 | -14 | 25 |
| 28 |
|
Nueva Chicago | 23 | 5 | 9 | 9 | 21:29 | -8 | 24 |
| 29 |
|
Temperley | 22 | 5 | 8 | 9 | 19:27 | -8 | 23 |
| 30 |
|
Atlanta | 23 | 4 | 10 | 9 | 18:23 | -5 | 22 |
| 31 |
|
San Telmo | 22 | 5 | 7 | 10 | 23:37 | -14 | 22 |
| 32 |
|
Sacachispas | 22 | 3 | 12 | 7 | 17:25 | -8 | 21 |
| 33 |
|
Tristan Suárez | 22 | 4 | 8 | 10 | 24:29 | -5 | 20 |
| 34 |
|
Atlético Rafaela | 23 | 3 | 11 | 9 | 21:27 | -6 | 20 |
| 35 |
|
Flandria | 22 | 4 | 8 | 10 | 23:30 | -7 | 20 |
| 36 |
|
Villa Dálmine | 22 | 2 | 11 | 9 | 23:36 | -13 | 17 |
| 37 |
|
Ramón Santamarina | 23 | 2 | 8 | 13 | 14:39 | -25 | 14 |
| Ascenso | |
| Playoff | |
| Playoff | |
| Descenso |
