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|
| 08.10.2021 | 19:30 | Unión de Santa Fe | - | Platense | 1:2 (0:1) | |
| 21:45 | Central Córdoba SdE | - | Huracán | 1:2 (1:1) | ||
| 09.10.2021 | 00:00 | Estudiantes | - | Rosario Central | 2:2 (1:1) | |
| 02:15 | Newell's Old Boys | - | Vélez Sarsfield | 1:2 (0:1) | ||
| 18:30 | Argentinos Juniors | - | Defensa y Justicia | 0:2 (0:0) | ||
| 18:30 | Sarmiento de Junín | - | Aldosivi | 3:0 (1:0) | ||
| 20:45 | Patronato de Paraná | - | Racing Club | 1:2 (0:0) | ||
| 23:00 | Banfield | - | River Plate | 0:1 (0:1) | ||
| 10.10.2021 | 01:15 | Boca Juniors | - | CA Lanús | 4:2 (2:1) | |
| 11.10.2021 | 19:30 | Arsenal de Sarandí | - | Godoy Cruz | 0:0 (0:0) | |
| 21:45 | San Lorenzo | - | Colón de Santa Fe | 1:2 (0:1) | ||
| 12.10.2021 | 00:00 | Independiente | - | Gimnasia de La Plata | 1:1 (1:1) | |
| 02:15 | Talleres de Córdoba | - | Atlético Tucumán | 2:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
River Plate | 15 | 10 | 3 | 2 | 29:11 | 18 | 33 |
| 2 |
|
Talleres de Córdoba | 15 | 10 | 2 | 3 | 24:13 | 11 | 32 |
| 3 |
|
Estudiantes | 15 | 7 | 5 | 3 | 24:15 | 9 | 26 |
| 4 |
|
CA Lanús | 15 | 8 | 2 | 5 | 26:24 | 2 | 26 |
| 5 |
|
Vélez Sarsfield | 15 | 6 | 6 | 3 | 22:12 | 10 | 24 |
| 6 |
|
Boca Juniors | 15 | 6 | 6 | 3 | 16:12 | 4 | 24 |
| 7 |
|
Independiente | 15 | 6 | 6 | 3 | 17:14 | 3 | 24 |
| 8 |
|
Colón de Santa Fe | 15 | 6 | 5 | 4 | 12:16 | -4 | 23 |
| 9 |
|
Godoy Cruz | 15 | 6 | 4 | 5 | 25:20 | 5 | 22 |
| 10 |
|
Racing Club | 15 | 5 | 7 | 3 | 13:8 | 5 | 22 |
| 11 |
|
Huracán | 15 | 5 | 7 | 3 | 12:9 | 3 | 22 |
| 12 |
|
Defensa y Justicia | 15 | 5 | 6 | 4 | 18:12 | 6 | 21 |
| 13 |
|
Argentinos Juniors | 15 | 5 | 6 | 4 | 12:10 | 2 | 21 |
| 14 |
|
Sarmiento de Junín | 15 | 5 | 4 | 6 | 15:16 | -1 | 19 |
| 15 |
|
Gimnasia de La Plata | 15 | 4 | 6 | 5 | 12:16 | -4 | 18 |
| 16 |
|
Unión de Santa Fe | 15 | 5 | 3 | 7 | 15:20 | -5 | 18 |
| 17 |
|
Rosario Central | 15 | 5 | 2 | 8 | 20:21 | -1 | 17 |
| 18 |
|
San Lorenzo | 15 | 4 | 5 | 6 | 13:17 | -4 | 17 |
| 19 |
|
Platense | 15 | 3 | 7 | 5 | 17:19 | -2 | 16 |
| 20 |
|
Newell's Old Boys | 15 | 4 | 4 | 7 | 17:23 | -6 | 16 |
| 21 |
|
Atlético Tucumán | 15 | 4 | 4 | 7 | 12:20 | -8 | 16 |
| 22 |
|
Patronato de Paraná | 15 | 3 | 6 | 6 | 11:16 | -5 | 15 |
| 23 |
|
Banfield | 15 | 2 | 8 | 5 | 10:14 | -4 | 14 |
| 24 |
|
Aldosivi | 15 | 4 | 1 | 10 | 16:29 | -13 | 13 |
| 25 |
|
Arsenal de Sarandí | 15 | 2 | 6 | 7 | 6:20 | -14 | 12 |
| 26 |
|
Central Córdoba SdE | 15 | 2 | 5 | 8 | 15:22 | -7 | 11 |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Libertadores | |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Sudamericana | |
| Copa Sudamericana |
