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| I | Zamalek | - | St. George SC | 1:1 | ||
| V | St. George SC | - | Zamalek | 2:2 | ||
| I: 20.04.2013 19:00 | V: 05.05.2013 15:30 | Campeones: Zamalek | ||||
| I | JSM Béjaïa | - | Espérance de Tunis | 0:0 | ||
| V | Espérance de Tunis | - | JSM Béjaïa | 1:0 (0:0) | ||
| I: 20.04.2013 19:00 | V: 04.05.2013 17:00 | Campeones: Espérance de Tunis | ||||
| I | Orlando Pirates | - | TP Mazembe | 3:1 | ||
| V | TP Mazembe | - | Orlando Pirates | 1:0 | ||
| I: 20.04.2013 20:15 | V: 05.05.2013 15:30 | Campeones: Orlando Pirates | ||||
| I | CA Bizertin | - | Al Ahly SC | 0:0 | ||
| V | Al Ahly SC | - | CA Bizertin | 2:1 | ||
| I: 21.04.2013 16:00 | V: 05.05.2013 19:00 | Campeones: Al Ahly SC | ||||
| I | Coton Sport Garoua | - | Stade Malien | 3:0 | ||
| V | Stade Malien | - | Coton Sport Garoua | 0:0 | ||
| I: 21.04.2013 16:30 | V: 04.05.2013 18:00 | Campeones: Coton Sport Garoua | ||||
| I | AC Léopards | - | ES Sétif | 3:1 | ||
| V | ES Sétif | - | AC Léopards | 3:2 pn. | ||
| I: 21.04.2013 16:30 | V: 03.05.2013 19:00 | Campeones: ES Sétif | ||||
| I | Enugu Rangers | - | CRD Libolo | 0:0 | ||
| V | CRD Libolo | - | Enugu Rangers | 3:1 | ||
| I: 21.04.2013 17:00 | V: 04.05.2013 16:00 | Campeones: CRD Libolo | ||||
| I | FUS de Rabat | - | Séwé Sport | 1:1 | ||
| V | Séwé Sport | - | FUS de Rabat | 0:0 | ||
| I: 21.04.2013 21:00 | V: 04.05.2013 17:30 | Campeones: Séwé Sport | ||||
