| 1. Jornada | 26.07.2021 | CF Monterrey | - | Puebla FC | 1:1 | ||||
| 2. Jornada | 01.08.2021 | CF Monterrey | - | Pumas UNAM | 2:0 | ||||
| 3. Jornada | 07.08.2021 | Mazatlán FC | - | CF Monterrey | 1:1 | ||||
| 4. Jornada | 15.08.2021 | CF Monterrey | - | CF Pachuca | 3:1 | ||||
| 6. Jornada | 22.08.2021 | CF Monterrey | - | Deportivo Guadalajara | 0:0 | ||||
| 7. Jornada | 28.08.2021 | Club Tijuana | - | CF Monterrey | 2:2 | ||||
| 8. Jornada | 12.09.2021 | Atlas Guadalajara | - | CF Monterrey | 2:1 | ||||
| 9. Jornada | 20.09.2021 | CF Monterrey | - | UANL Tigres | 2:0 | ||||
| 13. Jornada | 17.10.2021 | CF Monterrey | - | Club León | 0:1 |  |
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| 14. Jornada | 20.10.2021 | Gallos Blancos | - | CF Monterrey | 1:0 | ||||
| 15. Jornada | 24.10.2021 | CF Monterrey | - | Club Necaxa | 0:1 | ||||
| 16. Jornada | 01.11.2021 | Atlético San Luis | - | CF Monterrey | 1:1 | ||||
| 17. Jornada | 07.11.2021 | CF América | - | CF Monterrey | 0:0 |
Paraguay