| 3. Jornada | 12.09.2021 | CyD Leonesa | - | Bilbao Athletic | 2:1 | ||||
| 14. Jornada | 28.11.2021 | CD Calahorra | - | CyD Leonesa | 2:0 | ||||
| 15. Jornada | 05.12.2021 | CyD Leonesa | - | Celta B | 0:1 | ||||
| 16. Jornada | 11.12.2021 | Zamora CF | - | CyD Leonesa | 2:2 |  |
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| 17. Jornada | 19.12.2021 | CyD Leonesa | - | Deportivo | 2:3 | ||||
| 18. Jornada | 08.01.2022 | UD Logroñés | - | CyD Leonesa | 0:0 | ||||
| 19. Jornada | 22.01.2022 | CyD Leonesa | - | Real Unión | 1:1 | ||||
| 20. Jornada | 25.01.2022 | Bilbao Athletic | - | CyD Leonesa | 1:2 | ||||
| 24. Jornada | 19.02.2022 | Extremadura UD | - | CyD Leonesa | 1:3 | ||||
| 25. Jornada | 26.02.2022 | CyD Leonesa | - | CD Tudelano | 3:1 | ||||
| 26. Jornada | 04.03.2022 | Rayo Majadahonda | - | CyD Leonesa | 1:0 | ||||
| 27. Jornada | 13.03.2022 | CyD Leonesa | - | SD Logroñés | 2:2 | ||||
| 28. Jornada | 19.03.2022 | Deportivo | - | CyD Leonesa | 2:1 | ||||
| 30. Jornada | 03.04.2022 | Real Unión | - | CyD Leonesa | 1:1 | ||||
| 31. Jornada | 09.04.2022 | CyD Leonesa | - | Racing de Ferrol | 0:2 | ||||
| 32. Jornada | 17.04.2022 | UD SS Reyes | - | CyD Leonesa | 0:3 | ||||
| 37. Jornada | 21.05.2022 | CF Talavera | - | CyD Leonesa | 0:5 | ||||
| 38. Jornada | 28.05.2022 | CyD Leonesa | - | UD Logroñés | 1:2 |
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