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| 21.05.2022 | Extremadura UD | - | Real Unión | no jug. | ||
| 19:00 | CD Tudelano | - | UD SS Reyes | 0:2 (0:0) | ||
| 20:30 | Celta B | - | Racing de Ferrol | 0:1 (0:0) | ||
| 20:30 | Bilbao Athletic | - | Real Racing | 2:1 (2:0) | ||
| 20:30 | Unionistas CF | - | CD Calahorra | 3:0 (1:0) | ||
| 20:30 | Valladolid B | - | Deportivo | 0:4 (0:2) | ||
| 20:30 | UD Logroñés | - | CD Badajoz | 1:0 (0:0) | ||
| 20:30 | Inter de Madrid | - | SD Logroñés | 3:1 (1:0) | ||
| 20:30 | Rayo Majadahonda | - | Zamora CF | 3:2 (1:1) | ||
| 20:30 | CF Talavera | - | CyD Leonesa | 0:5 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Real Racing | 37 | 24 | 7 | 6 | 59:31 | 28 | 79 |
| 2 |
|
Deportivo | 37 | 22 | 8 | 7 | 59:28 | 31 | 74 |
| 3 |
|
Racing de Ferrol | 37 | 20 | 9 | 8 | 48:26 | 22 | 69 |
| 4 |
|
Celta B | 37 | 17 | 9 | 11 | 59:45 | 14 | 60 |
| 5 |
|
Rayo Majadahonda | 37 | 18 | 5 | 14 | 48:46 | 2 | 59 |
| 6 |
|
UD Logroñés | 37 | 17 | 8 | 12 | 39:36 | 3 | 59 |
| 7 |
|
Unionistas CF | 37 | 15 | 13 | 9 | 54:37 | 17 | 58 |
| 8 |
|
Real Unión | 37 | 17 | 6 | 14 | 48:44 | 4 | 57 |
| 9 |
|
CD Badajoz | 37 | 14 | 14 | 9 | 39:28 | 11 | 56 |
| 10 |
|
CD Calahorra | 37 | 14 | 10 | 13 | 47:41 | 6 | 52 |
| 11 |
|
UD SS Reyes | 37 | 14 | 8 | 15 | 38:41 | -3 | 50 |
| 12 |
|
CyD Leonesa | 37 | 12 | 13 | 12 | 60:53 | 7 | 49 |
| 13 |
|
SD Logroñés | 37 | 12 | 11 | 14 | 42:42 | 0 | 47 |
| 14 |
|
Inter de Madrid | 37 | 11 | 13 | 13 | 46:49 | -3 | 46 |
| 15 |
|
Bilbao Athletic | 37 | 11 | 12 | 14 | 36:44 | -8 | 45 |
| 16 |
|
CF Talavera | 37 | 10 | 9 | 18 | 37:53 | -16 | 39 |
| 17 |
|
Valladolid B | 37 | 9 | 9 | 19 | 42:62 | -20 | 36 |
| 18 |
|
Zamora CF | 37 | 8 | 10 | 19 | 28:48 | -20 | 34 |
| 19 |
|
CD Tudelano | 37 | 7 | 7 | 23 | 32:51 | -19 | 28 |
| 20 |
|
Extremadura UD | 37 | 5 | 5 | 27 | 22:78 | -56 | 0 |
| Ascenso | |
| Playoff | |
| Descenso |
