| 1. Jornada | 24.07.2021 | Deportivo Guadalajara [Sub 20] | - | Atlético San Luis [Sub 20] | 1:5 | ||||
| 3. Jornada | 08.08.2021 | Pumas UNAM [Sub 20] | - | Atlético San Luis [Sub 20] | 5:3 | ||||
| 6. Jornada | 21.08.2021 | Atlético San Luis [Sub 20] | - | Cruz Azul [Sub 20] | 0:0 | ||||
| 7. Jornada | 27.08.2021 | Mazatlán FC [Sub 20] | - | Atlético San Luis [Sub 20] | 3:1 | ||||
| 8. Jornada | 10.09.2021 | Puebla FC [Sub 20] | - | Atlético San Luis [Sub 20] | 2:2 | ||||
| 14. Jornada | 21.09.2021 | FC Juárez [Sub 20] | - | Atlético San Luis [Sub 20] | 1:2 | ||||
| 10. Jornada | 26.09.2021 | Deportivo Toluca [Sub 20] | - | Atlético San Luis [Sub 20] | 2:0 | ||||
| 11. Jornada | 29.09.2021 | Atlético San Luis [Sub 20] | - | UANL Tigres [Sub 20] | 2:1 | ||||
| 12. Jornada | 02.10.2021 | Club León [Sub 20] | - | Atlético San Luis [Sub 20] | 2:0 | ||||
| 15. Jornada | 24.10.2021 | Atlético San Luis [Sub 20] | - | Atlas Guadalajara [Sub 20] | 0:2 | ||||
| 5. Jornada | 03.11.2021 | CF Pachuca [Sub 20] | - | Atlético San Luis [Sub 20] | 1:3 | ||||
| 17. Jornada | 07.11.2021 | Santos Laguna [Sub 20] | - | Atlético San Luis [Sub 20] | 2:1 |
México