| 4. Jornada | 19.09.2021 | Inter de Madrid | - | CyD Leonesa | 3:2 | ||||
| 5. Jornada | 25.09.2021 | CyD Leonesa | - | Valladolid B | 4:2 | ||||
| 6. Jornada | 02.10.2021 | CD Badajoz | - | CyD Leonesa | 3:3 |  |
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| 7. Jornada | 09.10.2021 | CyD Leonesa | - | CF Talavera | 1:2 | ||||
| 35. Jornada | 08.05.2022 | Celta B | - | CyD Leonesa | 5:3 | ||||
| 37. Jornada | 21.05.2022 | CF Talavera | - | CyD Leonesa | 0:5 | ||||
| 38. Jornada | 28.05.2022 | CyD Leonesa | - | UD Logroñés | 1:2 |
España