| 1. Jornada | 17.07.2021 | CA Lanús | - | Atlético Tucumán | 4:2 |  |
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| 2. Jornada | 24.07.2021 | Atlético Tucumán | - | Huracán | 1:0 | ||||
| 3. Jornada | 28.07.2021 | Godoy Cruz | - | Atlético Tucumán | 1:2 | |
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| 4. Jornada | 03.08.2021 | Atlético Tucumán | - | Vélez Sarsfield | 0:0 | ||||
| 5. Jornada | 08.08.2021 | Gimnasia de La Plata | - | Atlético Tucumán | 1:0 | ||||
| 6. Jornada | 14.08.2021 | Atlético Tucumán | - | Aldosivi | 2:2 | |
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| 8. Jornada | 24.08.2021 | Atlético Tucumán | - | Independiente | 2:0 |  |
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| 9. Jornada | 30.08.2021 | Newell's Old Boys | - | Atlético Tucumán | 1:2 | |
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| 10. Jornada | 04.09.2021 | Atlético Tucumán | - | Arsenal de Sarandí | 0:0 | |
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| 11. Jornada | 14.09.2021 | Central Córdoba SdE | - | Atlético Tucumán | 2:0 | ||||
| 12. Jornada | 19.09.2021 | Atlético Tucumán | - | Boca Juniors | 1:2 |  |
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| 15. Jornada | 12.10.2021 | Talleres de Córdoba | - | Atlético Tucumán | 2:0 | ||||
| 16. Jornada | 17.10.2021 | Atlético Tucumán | - | Argentinos Juniors | 4:3 | |
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| 19. Jornada | 30.10.2021 | Platense | - | Atlético Tucumán | 4:1 | |
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| 20. Jornada | 07.11.2021 | Atlético Tucumán | - | Racing Club | 0:2 | ||||
| 21. Jornada | 20.11.2021 | Rosario Central | - | Atlético Tucumán | 3:1 |
Argentina
Italia 