| 3. Jornada | 08.08.2021 | Pumas UNAM | - | Atlético San Luis | 1:3 | ||||
| 9. Jornada | 17.09.2021 | Atlético San Luis | - | Club Tijuana | 4:1 | ||||
| 10. Jornada | 26.09.2021 | Deportivo Toluca | - | Atlético San Luis | 1:2 | ||||
| 11. Jornada | 30.09.2021 | Atlético San Luis | - | UANL Tigres | 0:3 |  |
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| 12. Jornada | 03.10.2021 | Club León | - | Atlético San Luis | 0:0 | ||||
| 13. Jornada | 17.10.2021 | Atlético San Luis | - | CF América | 0:1 | ||||
| 15. Jornada | 25.10.2021 | Atlético San Luis | - | Atlas Guadalajara | 2:6 |  |
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| 16. Jornada | 01.11.2021 | Atlético San Luis | - | CF Monterrey | 1:1 | |
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| 5. Jornada | 04.11.2021 | CF Pachuca | - | Atlético San Luis | 0:0 |
Colombia